[单项选择]关于肝功能不全时药动学／药效学改变的说法中，正确的是（）
A. 血浆中结合型药物减少，游离型药物增多
B. 药物代谢减慢，清除率上升，半衰期缩短
C. 经胆汁分泌排泄的药物排泄加快
D. 药物分布容积减小
E. 经肝代谢药物的药效与毒副作用降低

患者男，39岁，因“反复头痛伴视力下降1年加重10d”来诊。近1年来常有头痛，性欲下降，逐渐出现阳痿等症状。实验室检查：血清PRL＞1000ng/ml（正常值1.90～25.00ng/ml），TT₃0.48nmol/L（正常值0.89～2.44nmol/L），TT₄41.43nmol/L（正常值62.68～150.80nmol/L），TSH1.173μU/ml（正常值0.500～4.940μU/ml），GH0.003ng/ml（正常值0～10ng/ml）。血浆皮质醇＜10ng/ml（8AM）。睾酮水平0.56ng/ml（成年男性正常值3.5～8.6ng/ml），鞍区MRI：31mm×19mm×16mm占位，包裹左侧海绵窦2/3以上。

患者女，35岁。患者自述4个月前发现耳后一肿物，开始约花生大小，现略增大，无不适。大体检查：灰红肿块，3.0cm×2.3cm×2.0cm，其切面灰红，质地中等，境界较清。低倍镜检：可见增生的血管，伴明显淋巴细胞及嗜酸粒细胞浸润。

The great American melting pot (熔炉) is beautifully simple in theory: colors, creeds and cultures stirred together in the land of the free. But the dally details are more difficult. 41)______ There are 43.6 million children attending public schools in America, and 2.6 million of them don’t speak English, an increase of 76% in the past decade. 42)______ . Citing the close Quebec secession vote in Canada as a warning signal, U.S. House Speaker Newt Gingrich said last week, "We should insist on English as a common language. That’s what binds us together." Senate majority leader and Republican presidential candidate Robert Dole recently made it an element of his campaign, declaring, "We must stop the practice of multilingual education as a means of instilling (渗透) ethnic pride or as a therapy for low self-esteems." Dole last week endorsed legislation to make English the "official language" of the U. S. 43) ______
44)_______But many cri